Neurobiology of Disease Alzheimer’s Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

Jinfang Wu,1 Md. Riyaz Basha,1 Brian Brock,1 David P. Cox,2 Fernando Cardozo-Pelaez,2 Christopher A. McPherson,3 Jean Harry,3 Deborah C. Rice,4 Bryan Maloney,5 Demao Chen,5 Debomoy K. Lahiri,5 and Nasser H. Zawia1 1Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, 2Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, 3National Institutes of Health, Research Triangle Park, North Carolina 27709, 4Maine Department of Health and Human Services, Augusta, Maine 04333, and 5Laboratory for Molecular Neurogenetics, Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202